Bayesian adaptive designs in single ascending dose trials in healthy volunteers
Author:
Affiliation:
1. ClinBAY SPRL; Genappe Belgium
2. F. Hoffmann-La Roche Ltd; Basel Switzerland
3. Roche Products; Welwyn UK
Publisher
Wiley
Subject
Pharmacology (medical),Pharmacology
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1111/bcp.12344/fullpdf
Reference27 articles.
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2. ‘Classical 3+3 design’ versus ‘accelerated titration designs’: analysis of 270 Phase 1 trials investigating anti-cancer agents;Penel;Invest New Drugs,2009
3. Evaluation of agile designs in first-in-human (FIH) trials - a simulation study;Perlstein;AAPS J,2009
4. Determination of the efficiency of first time-in-man designs in healthy volunteers;Chu;Clin Res Regul Aff,2008
5. Implementation of a Bayesian design in a dose-escalation study of an experimental agent in healthy volunteers;Zhou;Biometrics,2008
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