ELIOT : A platform to navigate the E3 pocketome and aid the design of new PROTACs
Author:
Affiliation:
1. Laboratory for Chemometrics and Molecular Modeling, Department of Chemistry, Biology, and Biotechnology University of Perugia Perugia Italy
2. Molecular Discovery Ltd., The Kinetic Centre Hertfordshire UK
3. Molecular Horizon Srl Bettona Italy
Publisher
Wiley
Subject
Molecular Medicine,Biochemistry,Drug Discovery,Pharmacology,Organic Chemistry
Link
https://onlinelibrary.wiley.com/doi/pdf/10.1111/cbdd.14123
Reference51 articles.
1. Ubiquitylation Pathways In Insulin Signaling and Organismal Homeostasis
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3. The Protein Data Bank
4. Catalytic in vivo protein knockdown by small-molecule PROTACs
5. Stick it to E3s
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3. PROTACable Is an Integrative Computational Pipeline of 3-D Modeling and Deep Learning To Automate the De Novo Design of PROTACs;Journal of Chemical Information and Modeling;2024-03-20
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