Searching for new <scp>mTOR</scp> kinase inhibitors: Analysis of binding sites and validation of docking protocols-Reference-Cited by-同舟云学术

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Searching for new mTOR kinase inhibitors: Analysis of binding sites and validation of docking protocols

Published:2022-08-09 Issue:1 Volume:101 Page:103-119
ISSN:1747-0277
Container-title:Chemical Biology & Drug Design
language:en
Short-container-title:Chem Biol Drug Des

Author:

Stary Dorota¹²³,Nepovimova Eugenie²,Kuca Kamil²,Bajda Marek¹²^ORCID

Affiliation:

1. Department of Physicochemical Drug Analysis, Faculty of Pharmacy Jagiellonian University Medical College Cracow Poland

2. Department of Chemistry, Faculty of Science University of Hradec Kralove Hradec Kralove Czech Republic

3. Doctoral School of Medical and Health Sciences Jagiellonian University Medical College Cracow Poland

Funder

Grantová Agentura České Republiky

Publisher

Wiley

Subject

Molecular Medicine,Biochemistry,Drug Discovery,Pharmacology,Organic Chemistry

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/cbdd.14126

Reference40 articles.

1. Architecture of human Rag GTPase heterodimers and their complex with mTORC1

2. Rapamycin increases lifespan and inhibits spontaneous tumorigenesis in inbred female mice

3. Architecture of human mTOR complex 1

4. 5-(4,6-Dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine (PQR309), a Potent, Brain-Penetrant, Orally Bioavailable, Pan-Class I PI3K/mTOR Inhibitor as Clinical Candidate in Oncology

5. The Protein Data Bank

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1. Discovery of small molecule mechanistic target of rapamycin inhibitors as anti-aging and anti-cancer therapeutics;Frontiers in Aging Neuroscience;2022-12-06

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