5-(4,6-Dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine (PQR309), a Potent, Brain-Penetrant, Orally Bioavailable, Pan-Class I PI3K/mTOR Inhibitor as Clinical Candidate in Oncology

Author:

Beaufils Florent1,Cmiljanovic Natasa1,Cmiljanovic Vladimir1,Bohnacker Thomas1,Melone Anna1,Marone Romina1,Jackson Eileen1,Zhang Xuxiao2,Sele Alexander1,Borsari Chiara1ORCID,Mestan Jürgen3,Hebeisen Paul3,Hillmann Petra3,Giese Bernd4,Zvelebil Marketa1,Fabbro Doriano3,Williams Roger L.2,Rageot Denise1,Wymann Matthias P.1ORCID

Affiliation:

1. Department of Biomedicine, University of Basel, Mattenstrasse 28, 4058 Basel, Switzerland

2. MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, U.K.

3. PIQUR Therapeutics AG, Hochbergerstrasse 60C, 4057 Basel, Switzerland

4. Department of Chemistry, University of Basel, St. Johanns-Ring 19, 4056 Basel, Switzerland

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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