Physiologically-based pharmacokinetic modelling of a CYP2C19 substrate, BMS-823778, utilizing pharmacogenetic data-Reference-Cited by-同舟云学术

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Physiologically-based pharmacokinetic modelling of a CYP2C19 substrate, BMS-823778, utilizing pharmacogenetic data

Published:2018-04-10 Issue:6 Volume:84 Page:1335-1345
ISSN:0306-5251
Container-title:British Journal of Clinical Pharmacology
language:en
Short-container-title:Br J Clin Pharmacol

Author:

Gong Jiachang¹^ORCID,Iacono Lisa²,Iyer Ramaswamy A.¹,Humphreys William G.¹,Zheng Ming³

Affiliation:

1. Pharmaceutical Candidate Optimization; Bristol-Myers Squibb; Princeton NJ 08543 USA

2. Global Regulatory Safety & Biometrics; Bristol-Myers Squibb; Princeton NJ 08543 USA

3. Clinical Pharmacology and Pharmacometrics; Bristol-Myers Squibb; Princeton NJ 08543 USA

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1111/bcp.13565/fullpdf

Reference35 articles.

1. Optimization of 1,2,4-triazolopyridines as inhibitors of human 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1);Li;ACS Med Chem Lett,2014

2. Continuous inhibition of 11beta-hydroxysteroid dehydrogenase type I in adipose tissue leads to tachyphylaxis in humans and rats but not in mice;Morentin Gutierrez;Br J Pharmacol,2015

3. 11β-HSD1 is the major regulator of the tissue-specific effects of circulating glucocorticoid excess;Morgan;Proc Natl Acad Sci,2014

4. Obesity and corticosteroids: 11β-hydroxysteroid type 1 as a cause and therapeutic target in metabolic disease;Morton;Mol Cell Endocrinol,2010

5. 11[beta]-Hydroxysteroid dehydrogenase types 1 and 2 activity in subcutaneous adipose tissue in humans: implications in obesity and diabetes;Dube;J Clin Endocrinol Metab,2015

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2. A physiologically based pharmacokinetic model of clopidogrel in populations of European and Japanese ancestry: An evaluation of CYP2C19 activity;Pharmacology Research & Perspectives;2022-03-20

3. Physiologically based pharmacokinetic (PBPK) modeling of meloxicam in different CYP2C9 genotypes;Archives of Pharmacal Research;2021-11-22

4. Reviewing Data Integrated for PBPK Model Development to Predict Metabolic Drug-Drug Interactions: Shifting Perspectives and Emerging Trends;Frontiers in Pharmacology;2021-10-28

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