Continuous inhibition of 11β-hydroxysteroid dehydrogenase type I in adipose tissue leads to tachyphylaxis in humans and rats but not in mice
Author:
Affiliation:
1. AstraZeneca R&D; Mereside, Alderley Park Macclesfield SK10 4TG UK
2. AstraZeneca R&D; Mölndal Sweden
3. Department of Medical Sciences; Uppsala University; 751 85 Uppsala Sweden
Publisher
Wiley
Subject
Pharmacology
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1111/bph.13251/fullpdf
Reference29 articles.
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3. A combined spectroscopic and crystallographic approach to probing drug-human serum albumin interactions;Buttar;Bioorg Med Chem,2010
4. 11beta-Hydroxysteroid dehydrogenase 1 reductase activity is dependent on a high ratio of NADPH/NADP(+) and is stimulated by extracellular glucose;Dzyakanchuk;Mol Cell Endocrinol,2009
5. Effects of an 11beta-hydroxysteroid dehydrogenase type 1 inhibitor, MK-0916, in patients with type 2 diabetes mellitus and metabolic syndrome;Feig;Diabetes Obes Metab,2011
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