AV-Block and Conduction Slowing Prevail Over TdP Arrhythmias in the Methoxamine-Sensitized Pro-Arrhythmic Rabbit Model

Author:

VARKEVISSER ROSANNE1,VOS MARC A.1,BEEKMAN JET D.1,TIELAND RALPH G.1,VAN DER HEYDEN MARCEL A.1

Affiliation:

1. Department of Medical Physiology; Division Heart & Lungs University Medical Center Utrecht; Utrecht The Netherlands

Funder

European Community's Seventh Framework Programme

Publisher

Wiley

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine

Reference42 articles.

1. QTU-prolongation and torsades de pointes induced by putative class III antiarrhythmic agents in the rabbit: Etiology and interventions;Carlsson;J Cardiovasc Pharmacol,1990

2. The anaesthetised methoxamine-sensitised rabbit model of torsades de pointes;Carlsson;Pharmacol Ther,2008

3. Combined potassium and calcium channel blocking activities as a basis for antiarrhythmic efficacy with low proarrhythmic risk: Experimental profile of BRL-32872;Bril;J Pharmacol Exp Ther,1996

4. Limited induction of torsade de pointes by terikalant and erythromycin in an in vivo model;Farkas;Eur J Pharmacol,2002

5. Biomarkers and endogenous determinants of dofetilide-induced torsades de pointes in alpha(1) -adrenoceptor-stimulated, anaesthetized rabbits;Farkas;Br J Pharmacol,2010

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