Dehydroevodiamine and hortiamine, alkaloids from the traditional Chinese herbal drug Evodia rutaecarpa, are IKr blockers with proarrhythmic effects in vitro and in vivo

Author:

Baburin Igor,Varkevisser Rosanne,Schramm Anja,Saxena Priyanka,Beyl Stanislav,Szkokan Phillip,Linder Tobias,Stary-Weinzinger Anna,van der Heyden Marcel A.G.,Houtman Marien,Takanari HirokiORCID,Jonsson MalinORCID,Beekman Jet H.D.,Hamburger MatthiasORCID,Vos Marc A.,Hering Steffen

Publisher

Elsevier BV

Subject

Pharmacology

Reference56 articles.

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3. International Conference on Harmonisation; guidance on S7B Nonclinical Evaluation of the Potential for Delayed Ventricular Repolarization (QT Interval Prolongation) by Human Pharmaceuticals; availability. Notice;Food and Drug Administration, HHS;Fed Regist.,2005

4. Rapidly progressive interstitial renal fibrosis in young women: association with slimming regimen including Chinese herbs;Vanherweghem;Lancet,1993

5. Mechanisms of vasorelaxant effect of dehydroevodiamine: a bioactive isoquinazolinocarboline alkaloid of plant origin;Chiou;J. Cardiovasc. Pharm.,1996

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