Interleukin‐6 and interferon‐alpha differentially regulate microglia function-Reference-Cited by-同舟云学术

Interleukin‐6 and interferon‐alpha differentially regulate microglia function

Published:2024-07-29 Issue:4 Volume:50 Page:
ISSN:0305-1846
Container-title:Neuropathology and Applied Neurobiology
language:en
Short-container-title:Neuropathology Appl Neurobio

Author:

Verdillo Rovin¹²,Spiteri Alanna²³,Viengkhou Barney¹²,Wishart Claire²³,King Nicholas J. C.²³,Hofer Markus J.¹²^ORCID

Affiliation:

1. School of Life and Environmental Sciences The University of Sydney Sydney NSW Australia

2. Charles Perkins Centre The University of Sydney Sydney NSW Australia

3. Viral Immunopathology Laboratory, Infection, Immunity and Inflammation Research Theme, School of Medical Sciences, Faculty of Medicine and Health The University of Sydney Sydney NSW Australia

Abstract

AbstractPrevious reports have shown that IL‐6 and IFN‐⍺ induce distinct transcriptomic and morphological changes in microglia. Here, we demonstrate that IL‐6 increases tissue surveillance, migration and phagocytosis in primary murine microglia, whereas IFN‐⍺ inhibits these functions. Our results provide a crucial link between transcriptome and function. It holds the potential to serve as the foundation for future studies aimed at identifying therapeutic targets for cytokine‐mediated neuroinflammatory diseases.

Publisher

Wiley

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/nan.13003

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4. Microglia have a more extensive and divergent response to interferon-α compared with astrocytes