Reduced current density, partially rescued by mexiletine, and depolarizing shift in activation of SCN5A W374G channels as a cause of severe form of Brugada syndrome-Reference-Cited by-同舟云学术

Reduced current density, partially rescued by mexiletine, and depolarizing shift in activation of SCN5A W374G channels as a cause of severe form of Brugada syndrome

Published:2021-01-19 Issue:3 Volume:26 Page:
ISSN:1082-720X
Container-title:Annals of Noninvasive Electrocardiology
language:en
Short-container-title:Ann Noninvasive Electrocardiol

Author:

Nakajima Tadashi¹^ORCID,Dharmawan Tommy¹,Kawabata‐Iwakawa Reika²^ORCID,Tamura Shuntaro¹,Hasegawa Hiroshi¹,Kobari Takashi¹,Ota Masaki³,Tange Shoichi⁴,Nishiyama Masahiko⁵^ORCID,Kaneko Yoshiaki¹^ORCID,Kurabayashi Masahiko¹^ORCID

Affiliation:

1. Department of Cardiovascular Medicine Gunma University Graduate School of Medicine Maebashi Japan

2. Division of Integrated Oncology Research Gunma University Initiative for Advanced Research Maebashi Japan

3. Department of Cardiovascular Medicine National Hospital Organization Takasaki General Medical Center Takasaki Japan

4. Department of Cardiovascular Medicine Japanese Red Cross Maebashi Hospital Maebashi Japan

5. Gunma University Maebashi Japan

Publisher

Wiley

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,General Medicine

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/anec.12828

Reference23 articles.

1. Cellular and ionic mechanisms responsible for the brugada syndrome

2. Right bundle branch block, persistent ST segment elevation and sudden cardiac death: A distinct clinical and electrocardiographic syndrome

3. Enhanced closed-state inactivation of mutant cardiac sodium channels (SCN5A N1541D and R1632C) through different mechanisms

4. Trafficking and functional expression of cardiac Na+ channels

5. Mexiletine rescues a mixed biophysical phenotype of the cardiac sodium channel arising from the SCN5A mutation, N406K, found in LQT3 patients

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1. Inherited channelopathies and acquired phenocopies;Genomic and Molecular Cardiovascular Medicine;2024

2. Loss of sodium current caused by a Brugada syndrome–associated variant is determined by patient-specific genetic background;Heart Rhythm;2023-11

3. Towards Mutation-Specific Precision Medicine in Atypical Clinical Phenotypes of Inherited Arrhythmia Syndromes;International Journal of Molecular Sciences;2021-04-10

4. Reduced current density, partially rescued by mexiletine, and depolarizing shift in activation of SCN5A W374G channels as a cause of severe form of Brugada syndrome;Annals of Noninvasive Electrocardiology;2021-01-19