1. Department of Pharmacotoxicology University Hospital Hospices Civils de LYON (HCL) Lyon France
2. CNRS, UMR5558, Laboratory of Biometry and Evolutionary Biology Lyon 1 University Lyon France
3. Department of Applied Mathematics and Modelization Polytech Lyon Lyon France
4. Department of Biostatistics, Hospices Civils de LYON (HCL) University Hospital Lyon France