Glucocerebrosidase 1 and leucine‐rich repeat kinase 2 in Parkinson disease and interplay between the two genes
Author:
Affiliation:
1. Department of Clinical and Movement Neurosciences UCL Queen Square Institute of Neurology London UK
2. Aligning Science Across Parkinson’s (ASAP) Collaborative Research Network Chevy Chase Maryland USA
Publisher
Wiley
Subject
Cellular and Molecular Neuroscience,Biochemistry
Link
https://onlinelibrary.wiley.com/doi/pdf/10.1111/jnc.15524
Reference166 articles.
1. Molecular insights of the G2019S substitution in LRRK2 kinase domain associated with Parkinson's disease: A molecular dynamics simulation approach
2. Constitutive silencing of LRRK2 kinase activity leads to early glucocerebrosidase deregulation and late impairment of autophagy in vivo
3. Comparison of Parkinson Risk in Ashkenazi Jewish Patients With Gaucher Disease andGBAHeterozygotes
4. Glucocerebrosidase activity in Parkinson’s disease with and withoutGBAmutations
5. LRRK2 inhibitors and their potential in the treatment of Parkinson’s disease: current perspectives
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2. Rotenone Blocks the Glucocerebrosidase Enzyme and Induces the Accumulation of Lysosomes and Autophagolysosomes Independently of LRRK2 Kinase in HEK-293 Cells;International Journal of Molecular Sciences;2023-06-24
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4. Genetic variations in GBA1 and LRRK2 genes: Biochemical and clinical consequences in Parkinson disease;Frontiers in Neurology;2022-08-12
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