Clonal hematopoiesis associated with epigenetic aging and clinical outcomes

Author:

Nachun Daniel1ORCID,Lu Ake T.2,Bick Alexander G.3,Natarajan Pradeep45,Weinstock Joshua6,Szeto Mindy D.7,Kathiresan Sekar45,Abecasis Goncalo6,Taylor Kent D.8,Guo Xiuqing8,Tracy Russ9,Durda Peter9,Liu Yongmei10,Johnson Craig11,Rich Stephen S.12,Van Den Berg David13,Laurie Cecilia11,Blackwell Tom6,Papanicolaou George J.14,Correa Adolfo15,Raffield Laura M.16,Johnson Andrew D.17ORCID,Murabito Joanne18,Manson JoAnn E.19,Desai Pinkal20,Kooperberg Charles21,Assimes Themistocles L.22,Levy Daniel17,Rotter Jerome I.8,Reiner Alex P.23,Whitsel Eric A.2425,Wilson James G.2627,Horvath Steve2ORCID,Jaiswal Siddhartha128,

Affiliation:

1. Department of Pathology Stanford University School of Medicine Stanford CA USA

2. Department of Human Genetics David Geffen School of Medicine University of California Los Angeles Los Angeles CA USA

3. Department of Medicine Vanderbilt University School of Medicine Nashville TN USA

4. Department of Medicine Massachusetts General Hospital Boston MA USA

5. Broad Institute Cambridge MA USA

6. Department of Biostatistics University of Michigan School of Public Health Ann Arbor MI USA

7. Division of Biomedical Informatics and Personalized Medicine Department of Medicine University of Colorado Anschutz Medical Campus Aurora CO USA

8. Department of Pediatrics The Institute for Translational Genomics and Population Sciences The Lundquist Institute for Biomedical Innovation at Harbor‐UCLA Medical Center Torrance CA USA

9. Department of Pathology and Laboratory Medicine Larner College of Medicine University of Vermont Burlington VT USA

10. Department of Medicine Duke University Medical Center Durham NC USA

11. Department of Biostatistics School of Public Health University of Washington Seattle WA USA

12. Center for Public Health Genomics University of Virginia Charlottesville VA USA

13. Department of Clinical Preventative Medicine Keck School of Medicine University of Southern California Los Angeles CA USA

14. Division of Cardiovascular Sciences National Heart, Lung, and Blood Institute Bethesda MD USA

15. Department of Medicine University of Mississippi Medical Center Jackson MS USA

16. Department of Genetics University of North Carolina School of Medicine Chapel Hill NC USA

17. National Heart Lung and Blood Institute Framingham MA USA

18. Department of Medicine Boston University School of Medicine Boston MA USA

19. Department of Medicine Brigham and Women's Hospital Harvard Medical School Boston MA USA

20. Department of Hematology/Oncology Joan & Sanford I. Weill Medical College of Cornell University New York NY USA

21. Public Health Sciences Division Fred Hutchinson Cancer Research Center Seattle WA USA

22. Department of Medicine Stanford University School of Medicine Stanford CA USA

23. Department of Epidemiology School of Public Health University of Washington Seattle WA USA

24. Department of Medicine University of North Carolina Chapel Hill NC USA

25. Department of Epidemiology Gillings School of Global Public Health Chapel Hill NC USA

26. Department of Cardiology Beth Israel Deaconess Medical Center Boston MA USA

27. Department of Physiology and Biophysics University of Mississippi Medical Center Jackson MS USA

28. Institute for Stem Cell Biology and Regenerative Medicine Stanford University School of Medicine Stanford CA USA

Funder

National Institute on Aging

Publisher

Wiley

Subject

Cell Biology,Aging

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