Impaired neutrophil extracellular trap formation: a novel defect in the innate immune system of aged individuals

Author:

Hazeldine Jon1,Harris Phillipa2,Chapple Iain L.2,Grant Melissa2,Greenwood Hannah3,Livesey Amy1,Sapey Elizabeth3,Lord Janet M.1

Affiliation:

1. MRC-ARUK Centre for Musculoskeletal Ageing Research; School of Immunity and Infection; Birmingham University Medical School; Birmingham B15 2TT UK

2. Department of Periodontology; School of Dentistry; University of Birmingham; Birmingham B15 2TT UK

3. School of Clinical and Experimental Medicine; The Medical School; University of Birmingham; Birmingham B15 2TT UK

Funder

Biotechnology and Biological sciences Research Council

Publisher

Wiley

Subject

Cell Biology,Ageing

Reference43 articles.

1. The induction by human interleukin-6 of apoptosis in the promonocytic cell line U937 and human neutrophils;Afford;J. Biol. Chem.,1992

2. Restoration of NET formation by gene therapy in CGD controls aspergillosis;Bianchi;Blood,2009

3. Neutrophil extracellular traps kill bacteria;Brinkmann;Science,2004

4. Neutrophil extracellular traps: how to generate and visualize them;Brinkmann;J. Vis. Exp.,2010

5. Senescence in innate immune responses: reduced neutrophil phagocytic capacity and CD16 expression in elderly humans;Butcher;J. Leukoc. Biol.,2001

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