Synthesis, Biological Evaluation, and Docking of Dihydropyrazole Sulfonamide Containing 2-hydroxyphenyl Moiety: A Series of Novel MMP-2 Inhibitors
Author:
Affiliation:
1. State Key Laboratory of Pharmaceutical Biotechnology; Nanjing University; Nanjing 210093 China
2. Department of Biotechnology; FCPD; Sindh Agriculture University; Tandojam Sindh Pakistan
3. Xuzhou Central Hospital; Xuzhou 221009 China
Funder
JS Agriculture Scientific Prop
Publisher
Wiley
Subject
Molecular Medicine,Biochemistry,Drug Discovery,Pharmacology,Organic Chemistry
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1111/cbdd.12604/fullpdf
Reference20 articles.
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2. Orally active MMP-1 sparing α-tetrahydropyranyl and α-piperidinyl sulfone matrix metalloproteinase (MMP) inhibitors with efficacy in cancer, arthritis, and cardiovascular disease;Becker;J Med Chem,2010
3. Matrix metalloproteinases in stem cell regulation and cancer;Kessenbrock;Matrix Biol,2015
4. Matrix metalloproteinases: what do they not do? New substrates and biological roles identified by murine models and proteomics;Rodríguez;Biochim Biophys Acta,2010
5. In vivo imaging of MMP-13 activity in the murine destabilised medial meniscus surgical model of osteoarthritis;Lim;Osteoarthritis Cartilage,2014
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