Design, Synthesis, Biological Evaluation, and Docking Study of Acetylcholinesterase Inhibitors: New Acridone-1,2,4-oxadiazole-1,2,3-triazole Hybrids

Author:

Mohammadi-Khanaposhtani Maryam1,Mahdavi Mohammad2,Saeedi Mina34,Sabourian Reyhaneh4,Safavi Maliheh5,Khanavi Mahnaz6,Foroumadi Alireza2,Shafiee Abbas2,Akbarzadeh Tahmineh14

Affiliation:

1. Department of Medicinal Chemistry; Faculty of Pharmacy; Tehran University of Medical Sciences; Tehran 14176 Iran

2. Department of Medicinal Chemistry; Faculty of Pharmacy and Pharmaceutical Sciences Research Center; Tehran University of Medical Sciences; Tehran 14176 Iran

3. Medicinal Plants Research Center; Faculty of Pharmacy; Tehran University of Medical Sciences; Tehran 14176 Iran

4. Persian Medicine and Pharmacy Research Center; Tehran University of Medical Sciences; Tehran 14176 Iran

5. Department of Biotechnology; Iranian Research Organization for Science and Technology; Tehran 14176 Iran

6. Department of Pharmacognosy; Tehran University of Medical Sciences; Tehran 14176 Iran

Funder

Research Council of Tehran University of Medical Sciences

Publisher

Wiley

Subject

Molecular Medicine,Biochemistry,Drug Discovery,Pharmacology,Organic Chemistry

Reference31 articles.

1. A century of Alzheimer's disease;Goedert;Science,2006

2. The cholinergic hypothesis of Alzheimer's disease: A review of progress;Francis;J Neurol Neurosurg Psychiatry,1999

3. Comparison of butyrylcholinesterase and acetylcholinesterase;Chatonnet;Biochem J,1989

4. The histochemical differentiation of types of cholinesterases and their localization in tissues of the cat;Koelle;J Pharmacol Exp Ther,1950

5. Abundant tissue butyrylcholinesterase and its possible function in the acetylcholinesterase knockout mouse;Li;J Neurochem,2000

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