Statin-induced Myopathy and Ubiquinone Levels in Serum - Results from a Prospective, Observational Study

Author:

Skilving Ilona1,Acimovic Jure23,Rane Anders1,Ovesjö Marie-Louise1,Björkhem-Bergman Linda4

Affiliation:

1. Division of Clinical Pharmacology; Department of Laboratory Medicine; Karolinska Institutet; Karolinska University Hospital; Huddinge Stockholm Sweden

2. Division of Clinical Chemistry; Department of Laboratory Medicine; Karolinska Institute; Karolinska University Hospital; Huddinge Stockholm Sweden

3. Institute of Biochemistry; Faculty of Medicine; University of Ljubljana; Ljubljana Slovenia

4. Division of Clinical Microbiology; Department of Laboratory Medicine; Karolinska Institute; Karolinska University Hospital; Huddinge Stockholm Sweden

Publisher

Wiley

Subject

Pharmacology,Toxicology,General Medicine

Reference25 articles.

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2. Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins;Baigent;Lancet,2005

3. Channelling of statin use towards low-risk population and patients with diabetes;Rikala;Basic Clin Pharmacol Toxicol,2013

4. Mild to moderate muscular symptoms with high-dosage statin therapy in hyperlipidemic patients-the PRIMO study;Bruckert;Cardiovasc Drugs Ther,2005

5. Narrative review: statin-related myopathy;Joy;Ann Intern Med,2009

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1. Resveratrol for protection against statin toxicity in C2C12 and H9c2 cells;Journal of Biochemical and Molecular Toxicology;2020-03-20

2. Oxidative stress as a possible mechanism of statin-induced myopathy;Inflammopharmacology;2018-03-24

3. Myotoxicity of statins: Mechanism of action;Pharmacology & Therapeutics;2017-07

4. Effect of Statin Treatment on Plasma 4β-Hydroxycholesterol Concentrations;Basic & Clinical Pharmacology & Toxicology;2016-01-14

5. mi RNA ‐27b levels are associated with CYP 3A activity in vitro and in vivo;Pharmacology Research & Perspectives;2015-10-27

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