Effect of Statin Treatment on Plasma 4β-Hydroxycholesterol Concentrations

Author:

Björkhem-Bergman Linda1,Nylén Hanna2,Eriksson Mats3,Parini Paolo2,Diczfalusy Ulf2

Affiliation:

1. Division of Clinical Microbiology; Department of Laboratory Medicine; Karolinska Institutet; Karolinska University Hospital; Huddinge Stockholm Sweden

2. Division of Clinical Chemistry; Department of Laboratory Medicine; Karolinska Institutet; Karolinska University Hospital; Huddinge Stockholm Sweden

3. Division of Endocrinology; Department of Medicine; Karolinska Institutet; Karolinska University Hospital; Huddinge Stockholm Sweden

Funder

Pfizer

Swedish Heart and Lung Foundation

Magnus Bergwalls Stiftelse

Karolinska Institutet

Publisher

Wiley

Subject

Pharmacology,Toxicology,General Medicine

Reference23 articles.

1. Significance of the minor cytochrome P450 3A isoforms;Daly;Clin Pharmacokinet,2006

2. Cytochrome P450 and gene activation-from pharmacology to cholesterol elimination and regression of atherosclerosis;Luoma;Eur J Clin Pharmacol,2008

3. 4β-hydroxycholesterol is a new endogenous CYP3A marker: relationship to CYP3A5 genotype, quinine 3-hydroxylation and sex in Koreans, Swedes and Tanzanians;Diczfalusy;Pharmacogenet Genomics,2008

4. Use of midazolam as a human cytochrome P450 3A probe: I. In vitro-in vivo correlations in liver transplant patients;Thummel;J Pharmacol Exp Ther,1994

5. Quinine compared to 4beta-hydroxycholesterol and midazolam as markers for CYP3A induction by rifampicin;Björkhem-Bergman;Drug Metab Pharmacokinet,2014

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