Tacrolimus Predose Concentrations Do Not Predict the Risk of Acute Rejection After Renal Transplantation: A Pooled Analysis From Three Randomized-Controlled Clinical Trials†

Author:

Bouamar R.1,Shuker N.2,Hesselink D. A.2,Weimar W.2,Ekberg H.3,Kaplan B.4,Bernasconi C.5,van Gelder T.

Affiliation:

1. Department of Hospital Pharmacy

2. Department of Internal Medicine; Erasmus MC; Rotterdam; the Netherlands

3. Department of Nephrology and Transplantation; Skane University Hospital; Malmö; Sweden

4. Department of Medicine, Department of Surgery, Department of Pharmacology; University of Arizona School of Medicine; Tucson; AZ

5. Limites Medical Research Ltd.; Vacallo; Switzerland

Publisher

Wiley

Subject

Pharmacology (medical),Transplantation,Immunology and Allergy

Reference21 articles.

1. Department of Health and Human Services, Health Resources and Services Administration, Healthcare Systems Bureau, Division of Transplantation (ed.);Recipients OPaTNaSRoT;Am J Transplant,2012

2. Trough tacrolimus concentrations in the first week after kidney transplantation are related to acute rejection;Borobia;Ther Drug Monit,2009

3. Low tacrolimus concentrations and increased risk of early acute rejection in adult renal transplantation;Staatz;Nephrol Dial Transplant,2001

4. Tacrolimus whole blood concentrations correlate closely to side-effects in renal transplant recipients;Bottiger;Br J Clin Pharmacol,1999

5. Relationship of FK506 whole blood concentrations and efficacy and toxicity after liver and kidney transplantation;Kershner;Transplantation,1996

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