c.451dupT in KLKB1 is common in Nigerians, confirming a higher prevalence of severe prekallikrein deficiency in Africans compared to Europeans

Author:

Adenaeuer Anke12,Ezigbo Eyiuche D.3ORCID,Fawzy Nazir Hanan45ORCID,Barco Stefano16ORCID,Trinchero Alice7,Laubert‐Reh Dagmar18,Strauch Konstantin9,Wild Philipp S.18,Lackner Karl J.12,Lämmle Bernhard11011ORCID,Rossmann Heidi12ORCID

Affiliation:

1. Center for Thrombosis and Hemostasis (CTH) University Medical Center of the Johannes Gutenberg University Mainz Mainz Germany

2. Institute of Clinical Chemistry and Laboratory Medicine University Medical Center of the Johannes Gutenberg University Mainz Mainz Germany

3. Thrombosis & Haemostasis unit, Department of Medical Laboratory Sciences, Faculty of Health Sciences & Technology, College of Medicine University of Nigeria, Enugu Campus Enugu Nigeria

4. Child Health Department Sultan Qaboos University Hospital Muscat Oman

5. Department of Pediatrics Alexandria Faculty of Medicine Alexandria Egypt

6. Clinic of Angiology University Hospital Zurich Zurich Switzerland

7. Department of Medical Oncology and Hematology University Hospital Zurich Zurich Switzerland

8. Preventive Cardiology and Preventive Medicine Center for Cardiology University Medical Center of the Johannes Gutenberg University Mainz Mainz Germany

9. Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI) University Medical Center of the Johannes Gutenberg University of Mainz Mainz Germany

10. Department of Hematology and Central Hematology Laboratory, Inselspital Bern University HospitalUniversity of Bern Bern Switzerland

11. Haemostasis Research Unit University College London London UK

Funder

Bundesministerium für Bildung und Forschung

Publisher

Wiley

Subject

Hematology

Cited by 7 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Conclusion from 50 years of reports on prekallikrein or high-molecular-weight kininogen deficiency;GTH Congress 2023 – 67th Annual Meeting of the Society of Thrombosis and Haemostasis Research – The patient as a benchmark;2023-02

2. Definite diagnosis of plasma prekallikrein deficiency should not be based exclusively on shortening of the aPTT upon prolonged pre‐incubation;International Journal of Laboratory Hematology;2022-04-04

3. Prekallikrein deficiency: Challenges in laboratory testing;International Journal of Laboratory Hematology;2022-04-04

4. Prekallikrein deficiency due to homozygous KLKB1 (+) mutation c.444_445insT (p.Ser151PhefsTer34);International Journal of Laboratory Hematology;2021-11-30

5. Comment on “Worldwide Distribution of PK Deficiency: the Defect Seems Mainly Concentrated in West African Countries and the United States.”;Mediterranean Journal of Hematology and Infectious Diseases;2021-02-26

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