Severe plasma prekallikrein deficiency: Clinical characteristics, novel KLKB1 mutations, and estimated prevalence

Author:

Barco Stefano12ORCID,Sollfrank Stefanie3,Trinchero Alice14,Adenaeuer Anke13,Abolghasemi Hassan56,Conti Laura7,Häuser Friederike3,Kremer Hovinga Johanna A.8ORCID,Lackner Karl J.13,Loewecke Felicia9,Miloni Erwin10,Vazifeh Shiran Nader11,Tomao Luigi712,Wuillemin Walter A.13,Zieger Barbara9,Lämmle Bernhard1814ORCID,Rossmann Heidi13

Affiliation:

1. Center for Thrombosis and Hemostasis University Medical Center Mainz Johannes Gutenberg University Mainz Germany

2. Clinic of Angiology University Hospital and University of Zurich Zurich Switzerland

3. Institute of Clinical Chemistry and Laboratory Medicine University Medical Center Mainz Johannes Gutenberg University Mainz Germany

4. Department of Medical Oncology and Hematology University Hospital and University of Zurich Zurich Switzerland

5. Pediatric Congenital Hematologic Disorders Research Center Research Institute for Children's Health Shahid Beheshti University of Medical Sciences Tehran Iran

6. Department of Pediatrics Baqiyatallah University of Medical Sciences Tehran Iran

7. Clinical Pathology IRCCS Regina Elena National Cancer Institute Rome Italy

8. Department of Hematology and Central Hematology Laboratory, Inselspital Bern University Hospital University of Bern Bern Switzerland

9. Zentrum für Kinder‐ und Jugendmedizin Klinik IV Universitätsklinikum Freiburg Freiburg Germany

10. Practicing Physician Bern Switzerland

11. Department of Hematology and Blood Banking Paramedical Faculty Shahid Beheshti University of Medical Sciences Tehran Iran

12. Department of Pediatric Hematology‐Oncology IRCCS Bambino Gesù Children's Hospital Roma Italy

13. Division of Hematology and Central Hematology Laboratory Department of Internal Medicine Kantonsspital Lucerne Lucerne Switzerland

14. Haemostasis Research Unit University College London London UK

Funder

German Federal Ministry of Education and Research

Publisher

Wiley

Subject

Hematology

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