Effects of bosentan (Ro 47-0203), an ETA-, ETB-receptor antagonist, on regional haemodynamic responses to endothelins in conscious rats

Author:

Gardiner S.M.,Kemp P.A.,March J.E.,Bennett T.

Publisher

Wiley

Subject

Pharmacology

Reference21 articles.

1. Endothelins: circulating plasma levels and presence in other biological fluids;BATTISTINI;Lab. Invest.,1993

2. Influence of an ETA-receptor antagonist on regional haemodynamic responses to endothelin-1 (ET-1) and [Ala11, 15]Ac-ET-1(6-21) in conscious rats;BENNETT;Br. J. Pharmacol.,1993

3. Discrimination between ETA-and ETB-receptor-mediated effects of endothelin-1 and [Ala1, 3,11, 15] endothelin-1 by BQ-123 in the anaesthetized rat;BIGAUD;Br. J. Pharmacol.,1992

4. Pathophysiological role of endothelin revealed by the first orally active endothelin receptor antagonist;CLOZEL;Nature,1993

5. Pharmacological characterization of bosentan, a new potent orally active non-peptide endothelin receptor antagonist;CLOZEL;J. Pharmacol. Exp. Ther.,1994

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