Affiliation:
1. Department of Epidemiology and Health Statistics School of Public Health, Capital Medical University Beijing China
2. Beijing Municipal Key Laboratory of Clinical Epidemiology Beijing China
3. Department of Neurology, Beijing Tiantan Hospital Capital Medical University Beijing China
4. China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital Capital Medical University Beijing China
5. Department of Cardiology, Kailuan Hospital North China University of Science and Technology Tangshan China
Abstract
AbstractMain ProblemInflammation plays an important role in the pathological progress associated with stroke. Serum uric acid (SUA) to lymphocyte ratio (ULR), a novel inflammatory biomarker, has been considered as a better risk stratification tool of adverse outcomes than SUA or lymphocyte alone. This study aimed to investigate whether ULR produced more predictive value for stroke and explore the potential mediators of the associations.MethodsThis study enrolled 93,023 Chinese participants without stroke and myocardial infarction at baseline. Cox proportional hazard models were used to analyze the associations of ULR with stroke and subtypes. Mediation analyses were conducted to explore potential mediators of the associations.ResultsDuring a median follow‐up of 13.00 years, 6081 cases of incident stroke occurred, including 5048 cases of ischemic stroke (IS) and 900 cases of hemorrhagic stroke (HS). After adjustment for confounders, the Q4 group was associated with a higher risk of HS (HR, 1.25; 95% CI, 1.03–1.50), but not with total stroke (HR, 1.07; 95% CI, 1.03–1.13) or IS (HR, 1.04; 95% CI, 0.97–1.12). No significant associations were found between SUA or lymphocyte and any stroke. ULR outperformed SUA or lymphocytes alone in predicting stroke. Additionally, the significant association between ULR and HS was partially mediated by systolic blood pressure (20.32%), diastolic blood pressure (11.18%) and estimated glomerular filtration rate (9.19%).ConclusionsULR was significantly associated with the risk of HS, but not with IS. Systolic blood pressure, diastolic blood pressure and estimated glomerular filtration rate were potential mediators for the association.
Funder
National Key Research and Development Program of China
Subject
Pharmacology (medical),Physiology (medical),Psychiatry and Mental health,Pharmacology
Cited by
3 articles.
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