Mibefradil, a T‐type Ca 2+ channel blocker also blocks Orai channels by action at the extracellular surface-Reference-Cited by-同舟云学术

Mibefradil, a T‐type Ca 2+ channel blocker also blocks Orai channels by action at the extracellular surface

Published:2019-08-19 Issue:19 Volume:176 Page:3845-3856
ISSN:0007-1188
Container-title:British Journal of Pharmacology
language:en
Short-container-title:Br J Pharmacol

Author:

Li Pengyun¹²,Rubaiy Hussein N.¹^ORCID,Chen Gui‐Lan¹²,Hallett Thomas¹,Zaibi Nawel¹,Zeng Bo²,Saurabh Rahul¹,Xu Shang‐Zhong¹^ORCID

Affiliation:

1. Centre for Atherothrombosis and Metabolic Disease, Hull York Medical SchoolUniversity of Hull Hull UK

2. Key Laboratory of Medical Electrophysiology, Ministry of Education, and Institute of Cardiovascular ResearchSouthwest Medical University Luzhou China

Funder

H2020 European Research Council

National Natural Science Foundation of China

Publisher

Wiley

Subject

Pharmacology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/bph.14788

Reference49 articles.

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2. THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Voltage-gated ion channels

3. R93W mutation in Orai1 causes impaired calcium influx in platelets

4. Voltage‐dependent blockade of diverse types of voltage‐gated Ca2+ channels expressed in Xenopus oocytes by the Ca2+ channel antagonist mibefradil (Ro 40‐5967);Bezprozvanny I.;Molecular Pharmacology,1995

5. Orai1 (CRACM1) is the platelet SOC channel and essential for pathological thrombus formation

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