Affiliation:
1. Key Laboratory of Medical Electrophysiology of Ministry of Education and Medical Electrophysiological Key Lab of Sichuan Province, Collaborative Innovation Center for Prevention and Treatment of Cardiovascular Disease, Institute of Cardiovascular Research, Southwest Medical University, Luzhou, China
Abstract
In this study, we observed that the purinergic receptor P2Y2 is critical in the regulation of vascular wall-resident CD34+ cells’ migration. ATP could activate STIM1-mediated extracellular Ca2+ entry by triggering STIM1 translocation to the plasma membrane, and knockdown of STIM1 prevented ERK/p38 activation-mediated cytoskeleton rearrangement and cell migration.
Funder
MOST | National Natural Science Foundation of China
SPDST | Natural Science Foundation of Sichuan Province
SPDST | Sichuan Province Science and Technology Support Program
Science and Technology Department of Sichuan Province
Sichuan Provincial Administration of Traditional Chinese Medicine
Publisher
American Physiological Society
Cited by
3 articles.
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