The anti-migraine component of butterbur extracts, isopetasin, desensitizes peptidergic nociceptors by acting on TRPA1 cation channel

Author:

Benemei Silvia1,De Logu Francesco1,Li Puma Simone1,Marone Ilaria Maddalena1,Coppi Elisabetta1,Ugolini Filippo1,Liedtke Wolfgang2,Pollastro Federica3,Appendino Giovanni3,Geppetti Pierangelo1ORCID,Materazzi Serena1,Nassini Romina1

Affiliation:

1. Department of Health Sciences, Section of Clinical Pharmacology and Headache Center; University of Florence; Florence Italy

2. Departments of Neurology, Anesthesiology and Neurobiology, Clinics for Headache, Head-Pain and Trigeminal Sensory Disorders; Duke University; Durham NC USA

3. Department of Pharmaceutical Sciences; University of Eastern Piedmont; Novara Italy

Funder

Regione Toscana

Publisher

Wiley

Subject

Pharmacology

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