Toxicological Effects during and following Persistent Insulin-Induced Hypoglycaemia in Healthy Euglycaemic Rats-Reference-Cited by-同舟云学术

Toxicological Effects during and following Persistent Insulin-Induced Hypoglycaemia in Healthy Euglycaemic Rats

Published:2017-05-03 Issue:1 Volume:121 Page:53-66
ISSN:1742-7835
Container-title:Basic & Clinical Pharmacology & Toxicology
language:en
Short-container-title:Basic Clin Pharmacol Toxicol

Author:

Jensen Vivi F. H.¹²,Mølck Anne-Marie²,Berthelsen Line O.²,Alifrangis Lene³,Andersen Lene⁴,Chapman Melissa⁵,Lykkesfeldt Jens¹,Bøgh Ingrid B.²

Affiliation:

1. Department of Veterinary and Animal Sciences; Section for Experimental Animal Models; Faculty of Health and Medical Sciences; University of Copenhagen; Copenhagen Denmark

2. Department of Toxicology; Safety Pharm and Pathology; Novo Nordisk A/S; Maaloev Denmark

3. Department of Development DMPK; Novo Nordisk A/S; Maaloev Denmark

4. Department of Diabetes Bioanalysis; Novo Nordisk A/S; Maaloev Denmark

5. Division of Toxicology; Envigo; Suffolk UK

Funder

LifePharm Centre

Novo Nordisk

Publisher

Wiley

Subject

Pharmacology,Toxicology,General Medicine

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1111/bcpt.12769/fullpdf

Reference42 articles.

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2. Contribution of hepatic glycogenolysis and gluconeogenesis in the defense against short-term insulin induced hypoglycemia in rats;Nascimento;Life Sci,2008

3. FDA Guidance for industry. Diabetes Mellitus: developing drugs and therapeutic biologicals for treatment and prevention 2008 https://www.fda.gov/downloads/drugs/guidancecomplianceregulatoryinformation/guidances/ucm071624.pdf

4. EMA Points to consider document on the non-clinical assessment of the carcinogenic potential of insulin analogues 2001

5. Recurrent moderate hypoglycemia ameliorates brain damage and cognitive dysfunction induced by severe hypoglycemia;Puente;Diabetes,2010

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