<scp>SARS‐CoV</scp>‐2 spike <scp>mRNA</scp> vaccine sequences circulate in blood up to 28 days after <scp>COVID</scp>‐19 vaccination-Reference-Cited by-同舟云学术

SARS‐CoV‐2 spike mRNA vaccine sequences circulate in blood up to 28 days after COVID‐19 vaccination

Published:2023-01-29 Issue:3 Volume:131 Page:128-132
ISSN:0903-4641
Container-title:APMIS
language:en
Short-container-title:APMIS

Author:

Castruita Jose Alfredo Samaniego¹,Schneider Uffe Vest¹,Mollerup Sarah¹,Leineweber Thomas Daell¹,Weis Nina²³,Bukh Jens²⁴,Pedersen Martin Schou¹⁵,Westh Henrik¹³

Affiliation:

1. Department of Clinical Microbiology Copenhagen University Hospital Amager‐Hvidovre Hvidovre Denmark

2. Department of Infectious Diseases Copenhagen University Hospital Amager‐Hvidovre Hvidovre Denmark

3. Institute of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark

4. Copenhagen Hepatitis C Program (CO‐HEP), Department of Immunology and Microbiology, Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark

5. Department of Clinical Microbiology Copenhagen University Hospital Rigshospitalet Copenhagen Denmark

Abstract

In Denmark, vaccination against Severe Acute Respiratory Syndrome Corona Virus 2 (SARS‐CoV‐2) has been with the Pfizer‐BioNTech (BTN162b2) or the Moderna (mRNA‐1273) mRNA vaccines. Patients with chronic hepatitis C virus (HCV) infection followed in our clinic received mRNA vaccinations according to the Danish roll‐out vaccination plan. To monitor HCV infection, RNA was extracted from patient plasma and RNA sequencing was performed on the Illumina platform. In 10 of 108 HCV patient samples, full‐length or traces of SARS‐CoV‐2 spike mRNA vaccine sequences were found in blood up to 28 days after COVID‐19 vaccination. Detection of mRNA vaccine sequences in blood after vaccination adds important knowledge regarding this technology and should lead to further research into the design of lipid‐nanoparticles and the half‐life of these and mRNA vaccines in humans.

Publisher

Wiley

Subject

Microbiology (medical),General Medicine,Immunology and Allergy,Pathology and Forensic Medicine

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/apm.13294

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