Discovery of Novel Allosteric Eg5 Inhibitors Through Structure-Based Virtual Screening-Reference-Cited by-同舟云学术

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Discovery of Novel Allosteric Eg5 Inhibitors Through Structure-Based Virtual Screening

Published:2016-03-06 Issue:2 Volume:88 Page:178-187
ISSN:1747-0277
Container-title:Chemical Biology & Drug Design
language:en
Short-container-title:Chem Biol Drug Des

Author:

Zhang Wei¹,Zhai Ling¹,Lu Wenyan¹,Boohaker Rebecca J.¹,Padmalayam Indira¹,Li Yonghe¹

Affiliation:

1. Drug Discovery Division; Southern Research Institute; 2000 9th Avenue South Birmingham AL USA

Funder

Southern Research Institute

National Institutes of Health

Alabama Innovation Fund

Publisher

Wiley

Subject

Molecular Medicine,Biochemistry,Drug Discovery,Pharmacology,Organic Chemistry

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1111/cbdd.12744/fullpdf

Reference70 articles.

1. Analysis of the kinesin superfamily: insights into structure and function;Miki;Trends Cell Biol,2005

2. Kinesin motor proteins as targets for cancer therapy;Huszar;Cancer Metastasis Rev,2009

3. Induction of apoptosis by an inhibitor of the mitotic kinesin KSP requires both activation of the spindle assembly checkpoint and mitotic slippage;Tao;Cancer Cell,2005

4. Discovery and biochemical characterization of selective ATP competitive inhibitors of the human mitotic kinesin KSP;Rickert;Arch Biochem Biophys,2008

5. Conformation-dependent ligand regulation of ATP hydrolysis by human KSP: activation of basal hydrolysis and inhibition of microtubule-stimulated hydrolysis by a single, small molecule modulator;Luo;J Am Chem Soc,2008

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3. Mechanisms by Which Kinesin-5 Motors Perform Their Multiple Intracellular Functions;International Journal of Molecular Sciences;2021-06-15

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