1. Department of Enzymology and Mechanistic Pharmacology, Oncology CEDD, Department of Medicinal Chemistry, Oncology CEDD, and Department of Oncology Biology, Oncology CEDD, GlaxoSmithKline, Collegeville, Pennsylvania 19426, and ExSAR Corporation, 11 Deer Park Drive, Suite 103, Monmouth Junction, New Jersey 08852