On Efficient and Accurate Calculation of SignificanceP-Values for Sequence Kernel Association Testing of Variant Set

Author:

Wu Baolin1,Guan Weihua1,Pankow James S.2

Affiliation:

1. Division of Biostatistics; School of Public Health, University of Minnesota; Minneapolis MN USA

2. Division of Epidemiology and Community Health; School of Public Health, University of Minnesota; Minneapolis MN USA

Funder

NIH

National Heart, Lung, and Blood Institute (NHLBI)

NIH through the American Recovery and Reinvestment Act of 2009 (ARRA)

Publisher

Wiley

Subject

Genetics (clinical),Genetics

Reference38 articles.

1. Detecting rare variant effects using extreme phenotype sampling in sequencing association studies;Barnett;Genet Epidemiol,2013

2. Rare MTNR1B variants impairing melatonin receptor 1B function contribute to type 2 diabetes;Bonnefond;Nat Genet,2012

3. Sequence kernel association test for quantitative traits in family samples;Chen;Genet Epidemiol,2013

4. Sequence kernel association test for survival traits;Chen;Genet Epidemiol,2014

5. Algorithm AS 155: The distribution of a linear combination of χ2 random variables;Davies;J R Stat Soc Ser C Appl Stat,1980

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