Characteristics and long‐term outcome in a large series of chronic myelomonocytic leukaemia patients including 104 formerly referred to as oligomonocytic-Reference-Cited by-同舟云学术

Characteristics and long‐term outcome in a large series of chronic myelomonocytic leukaemia patients including 104 formerly referred to as oligomonocytic

Published:2023-11-27 Issue: Volume: Page:
ISSN:0007-1048
Container-title:British Journal of Haematology
language:en
Short-container-title:Br J Haematol

Author:

Castaño‐Díez Sandra¹²³^ORCID,Pomares Helena⁴,Esteban Daniel¹,Guijarro Francesca³⁵,Jiménez‐Vicente Carlos¹²^ORCID,Zugasti Inés¹,Álamo José Ramón⁵^ORCID,Mayayo Víctor Torrecillas²,López‐Guerra Mònica³⁵⁶,de la Fuente Cristina⁷,Charry Paola⁸,Cortés‐Bullich Albert¹,Bataller Álex¹²³⁹,Maluquer Clara⁴,Colomer Dolors³⁵⁶,Rozman María³⁵,Arnan Montserrat⁴,Xicoy Blanca⁷⁹^ORCID,Esteve Jordi¹²³⁹^ORCID,Díaz‐Beyá Marina¹³⁹^ORCID

Affiliation:

1. Hematology Department Hospital Clínic Barcelona Barcelona Spain

2. Universitat de Barcelona Barcelona Spain

3. Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) Barcelona Spain

4. Hematology Department, Institut Català d'Oncologia (ICO), Hospital Duran i Reynals, Hospitalet de Llobregat, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL) Universitat de Barcelona Barcelona Spain

5. Hematopathology Section, Servei d'Anatomia Patològica, CDB Hospital Clínic Barcelona Barcelona Spain

6. Centro de Investigación Biomédica en Red de Cáncer (CIBERONC) Madrid Spain

7. Hematology Department, Institut Català d'Oncologia (ICO), Hospital Germans Trias i Pujol, Badalona Universitat Autònoma de Barcelona Barcelona Spain

8. Apheresis Department Hospital Clínic Barcelona Barcelona Spain

9. Josep Carreras Leukaemia Research Institute Badalona Spain

Abstract

SummaryRecently modified diagnostic criteria for chronic myelomonocytic leukaemia (CMML) have lowered the cut‐off for absolute monocytosis. In the largest series to date, we have analysed 313 CMML patients, including 104 with oligomonocytic (OM)‐CMML. Five‐year survival was longer for OM‐CMML than for other patients (p < 0.001). Multivariate analysis identified OM‐CMML as a favourable prognostic factor (HR 0.58; p = 0.002). The 5‐year cumulative incidence of progression to classical CMML was 47%. Older age and transfusion dependence were adverse prognostic factors for OM‐CMML. Our results support the inclusion of OM‐CMML in the CMML category as a subtype with superior outcomes.

Funder

Instituto de Salud Carlos III

Publisher

Wiley

Subject

Hematology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/bjh.19217

Reference13 articles.

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2. The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Myeloid and Histiocytic/Dendritic Neoplasms

3. Oligomonocytic chronic myelomonocytic leukemia (chronic myelomonocytic leukemia without absolute monocytosis) displays a similar clinicopathologic and mutational profile to classical chronic myelomonocytic leukemia

4. Myelodysplastic syndromes without peripheral monocytosis but with evidence of marrow monocytosis share clinical and molecular characteristics with CMML

5. Proposed diagnostic criteria for classical chronic myelomonocytic leukemia (CMML), CMML variants and pre-CMML conditions

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1. Should oligomonocytic CMML be classified as an independent disease entity?;British Journal of Haematology;2023-12-08