Investigation of bioequivalence of a new fixed-dose combination of acarbose and metformin with the corresponding loose combination as well as the drug-drug interaction potential between both drugs in healthy adult male subjects
Author:
Affiliation:
1. Department of Clinical Pharmacology and Therapeutics; Seoul National University College of Medicine and Hospital; Seoul Korea
2. Development Clinical Pharmacology Asia/PC; Bayer HealthCare Global R&D Center; Beijing China
Funder
Bayer Healthcare Company Limited
Publisher
Wiley
Subject
Pharmacology (medical),Pharmacology
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1111/jcpt.12166/fullpdf
Reference26 articles.
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2. Rationale and options for combination therapy in the treatment of Type 2 diabetes;Gaal;Diabetologia,2003
3. Efficacy and safety of acarbose add-on therapy in the treatment of overweight patients with Type 2 diabetes inadequately controlled with metformin: a double-blind, placebo-controlled study;Halimi;Diabetes Res Clin Pract,2000
4. A randomized double-blind trial of acarbose in type 2 diabetes shows improved glycemic control over 3 years (U.K. Prospective Diabetes Study 44);Holman;Diabetes Care,1999
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