A comprehensive approach to identifying repurposed drugs to treat SCN8A epilepsy-Reference-Cited by-同舟云学术

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A comprehensive approach to identifying repurposed drugs to treat SCN8A epilepsy

Published:2018-03-25 Issue:4 Volume:59 Page:802-813
ISSN:0013-9580
Container-title:Epilepsia
language:en
Short-container-title:Epilepsia

Author:

Atkin Talia A.¹,Maher Chani M.¹,Gerlach Aaron C.²,Gay Bryant C.¹,Antonio Brett M.²,Santos Sonia C.²,Padilla Karen M.²,Rader JulieAnn¹,Krafte Douglas S.²,Fox Matthew A.¹,Stewart Gregory R.¹,Petrovski Slavé¹³,Devinsky Orrin¹⁴,Might Matthew¹⁵,Petrou Steven¹³,Goldstein David B.¹⁶

Affiliation:

1. Pairnomix; Plymouth MN USA

2. Icagen; Durham NC USA

3. Florey Institute for Neuroscience and Mental Health and Department of Medicine, Royal Melbourne Hospital; University of Melbourne; Parkville Victoria Australia

4. Department of Neurology; New York University Medical Center; New York NY USA

5. University of Alabama at Birmingham; Birmingham AL USA

6. Institute for Genomic Medicine; Columbia University Medical Center; New York NY USA

Funder

Pairnomix

Publisher

Wiley

Subject

Clinical Neurology,Neurology

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1111/epi.14037/fullpdf

Reference28 articles.

1. Rare diseases and orphan drugs;Melnikova;Nat Rev Drug Discov,2012

2. A roadmap for precision medicine in the epilepsies;EpiPM Consortium;Lancet Neurol,2015

3. Sodium channel Na(v)1.6 is localized at nodes of Ranvier, dendrites, and synapses;Caldwell;Proc Natl Acad Sci U S A,2000

4. Distinct contributions of Na(v)1.6 and Na(v)1.2 in action potential initiation and backpropagation;Hu;Nat Neurosci,2009

5. Electrophysiological properties of two axonal sodium channels, Nav1.2 and Nav1.6, expressed in mouse spinal sensory neurones;Rush;J Physiol,2005

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1. Carvedilol increases seizure resistance in a mouse model of SCN8A-derived epilepsy;Frontiers in Pharmacology;2024-06-04

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3. Steps to Improve Precision Medicine in Epilepsy;Molecular Diagnosis & Therapy;2023-09-27

4. Dissolution mechanism of supported phospholipid bilayer in the presence of amphiphilic drug investigated by neutron reflectometry and quartz crystal microbalance with dissipation monitoring;Biochimica et Biophysica Acta (BBA) - Biomembranes;2022-10

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