Precision medicine for genetic epilepsy on the horizon: Recent advances, present challenges, and suggestions for continued progress

Author:

Knowles Juliet K.1ORCID,Helbig Ingo23456ORCID,Metcalf Cameron S.7ORCID,Lubbers Laura S.8ORCID,Isom Lori L.9ORCID,Demarest Scott10ORCID,Goldberg Ethan M.235ORCID,George Alfred L.11ORCID,Lerche Holger12ORCID,Weckhuysen Sarah13141516ORCID,Whittemore Vicky17,Berkovic Samuel F.18ORCID,Lowenstein Daniel H.19ORCID

Affiliation:

1. Department of Neurology, Division of Child Neurology Stanford University School of Medicine Stanford California USA

2. Division of Neurology Children’s Hospital of Philadelphia Philadelphia Pennsylvania USA

3. Epilepsy NeuroGenetics Initiative, Children's Hospital of Philadelphia Philadelphia Pennsylvania USA

4. Department of Biomedical and Health Informatics Children’s Hospital of Philadelphia Philadelphia Pennsylvania USA

5. Department of Neurology University of Pennsylvania, Perelman School of Medicine Philadelphia Pennsylvania USA

6. Institute of Clinical Molecular Biology, University of Kiel Kiel Germany

7. Department of Pharmacology and Toxicology, College of Pharmacy University of Utah Salt Lake City Utah USA

8. Citizens United for Research in Epilepsy Chicago Illinois USA

9. Department of Pharmacology University of Michigan Medical School Ann Arbor Michigan USA

10. Department of Pediatrics and Neurology University of Colorado, School of Medicine Aurora Colorado USA

11. Department of Pharmacology Northwestern University Feinberg School of Medicine Chicago Illinois USA

12. Department of Neurology and Epileptology Hertie Institute for Clinical Brain Research, University of Tübingen Tübingen Germany

13. Division of Neurology University Hospital Antwerp Antwerp Belgium

14. Applied and Translational Neurogenomics Group Vlaams Instituut voor Biotechnologie Center for Molecular Neurology Antwerp Belgium

15. Translational Neurosciences, Faculty of Medicine and Health Science University of Antwerp Antwerp Belgium

16. μNEURO Research Center of Excellence University of Antwerp Antwerp Belgium

17. Division of Neuroscience National Institute of Neurological Disorders and Stroke, National Institutes of Health Rockville Maryland USA

18. Epilepsy Research Centre, Department of Medicine Austin Health, University of Melbourne Melbourne Victoria Australia

19. Department of Neurology University of California, San Francisco San Francisco California USA

Funder

Burroughs Wellcome Fund

Child Neurology Foundation

Deutsche Forschungsgemeinschaft

Fonds Wetenschappelijk Onderzoek

Hartwell Foundation

Institute for Translational Medicine and Therapeutics

International Foundation for CDKL5 Research

National Health and Medical Research Council

National Institute of Neurological Disorders and Stroke

Stanford Maternal and Child Health Research Institute

Publisher

Wiley

Subject

Neurology (clinical),Neurology

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