Elevations of metabolic risk factors 20 years or more before diagnosis of type 2 diabetes: Experience from the AMORIS study

Author:

Malmström Håkan12ORCID,Walldius Göran1,Carlsson Sofia1,Grill Valdemar34,Jungner Ingmar25,Gudbjörnsdottir Soffia6,Kosiborod Mikhail7,Hammar Niklas18

Affiliation:

1. Unit of Epidemiology; Institute of Environmental Medicine, Karolinska Institute; Stockholm Sweden

2. Swedish Orphan Biovitrum AB; Stockholm Sweden

3. Department of Clinical and Molecular Medicine; Norwegian University of Science and Technology; Trondheim Norway

4. Department of Endocrinology; Trondheim University Hospital; Trondheim Norway

5. CALAB Research; Stockholm Sweden

6. Department of Medicine, Sahlgrenska Academy; University of Gothenburg; Gothenburg Sweden

7. Saint Luke's Mid America Heart Institute and University of Missouri-Kansas City; Kansas City Missouri

8. Medical Evidence and Observational Research, Global Medical Evidence and Observational Research, AstraZeneca; Gothenburg Sweden

Funder

Gunnar and Ingmar Jungner Foundation for Laboratory Medicine

Fondation pour la Médecine de Laboratoire

Publisher

Wiley

Subject

Endocrinology,Endocrinology, Diabetes and Metabolism,Internal Medicine

Reference27 articles.

1. Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes;Lyssenko;J Clin Invest,2007

2. The many faces of diabetes: a disease with increasing heterogeneity;Tuomi;Lancet,2014

3. Triglyceride levels and risk of type 2 diabetes mellitus: a longitudinal large study;Beshara;J Invest Med,2016

4. A lifestyle intervention in primary care prevents deterioration of insulin resistance in patients with impaired glucose tolerance: a randomised controlled trial;Hellgren;Scand J Public Health.,2016

5. Risk models and scores for type 2 diabetes: systematic review;Noble;BMJ,2011

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