Clonal expansion of mitochondrial DNA deletions is a private mechanism of aging in long-lived animals

Author:

Lakshmanan Lakshmi Narayanan12,Yee Zhuangli3,Ng Li Fang4,Gunawan Rudiyanto12,Halliwell Barry3,Gruber Jan34

Affiliation:

1. Institute for Chemical and Bioengineering; ETH Zurich; Zurich Switzerland

2. Swiss Institute of Bioinformatics, Quartier Sorge - Batiment Genopode; Lausanne Switzerland

3. Department of Biochemistry; Yong Loo Lin School of Medicine, National University of Singapore; Singapore

4. Ageing Research Laboratory, Science Division; Yale-NUS College; Singapore Singapore

Funder

Ministry of Education - Singapore

Ministerul Educatiei Nationale

Publisher

Wiley

Subject

Cell Biology,Ageing

Reference62 articles.

1. The maintenance of mitochondrial DNA integrity-critical analysis and update;Alexeyev;Cold Spring Harbor Perspectives in Biology.,2013

2. Ultra-deep sequencing of mouse mitochondrial DNA: Mutational patterns and their origins;Ameur;PLoS Genetics,2011

3. Human stem cell aging: Do mitochondrial DNA mutations have a causal role?;Baines;Aging Cell,2014

4. High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease;Bender;Nature Genetics,2006

5. Mitochondrial dynamics and autophagy aid in removal of persistent mitochondrial DNA damage in Caenorhabditis elegans;Bess;Nucleic Acids Research,2012

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