Human stem cell aging: do mitochondrial DNA mutations have a causal role?

Author:

Baines Holly L.1,Turnbull Douglass M.12,Greaves Laura C.1

Affiliation:

1. Centre for Brain Ageing and Vitality; Institute for Ageing and Health; The Medical School; Newcastle upon Tyne NE2 4HH UK

2. Wellcome Trust centre for Mitochondrial Research; Institute for Ageing and Health; Newcastle University; Newcastle upon Tyne NE2 4HH UK

Funder

Medical Research Council

Wellcome Trust

Publisher

Wiley

Subject

Cell Biology,Aging

Reference43 articles.

1. Somatic progenitor cell vulnerability to mitochondrial DNA mutagenesis underlies progeroid phenotypes in polg mutator mice;Ahlqvist;Cell Metab.,2012

2. Ultra-deep sequencing of mouse mitochondrial DNA: mutational patterns and their origins;Ameur;PLoS Genet.,2011

3. Sequence and organization of the human mitochondrial genome;Anderson;Nature,1981

4. High oxidative damage levels in the longest-living rodent, the naked mole-rat;Andziak;Aging Cell,2006

5. Distribution and threshold expression of the tRNA(Lys) mutation in skeletal muscle of patients with myoclonic epilepsy and ragged-red fibers (MERRF);Boulet;Am. J. Hum. Genet.,1992

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