Extracellular 2′5′-oligoadenylate synthetase 2 mediates T-cell receptor CD3-ζchain down-regulation via caspase-3 activation in oral cancer

Author:

Dar Asif A.1,Pradhan Trupti N.1,Kulkarni Dakshayni P.1,Shah Sagar U.1,Rao Kanury V.2,Chaukar Devendra A.3,D'Cruz Anil K.3,Chiplunkar Shubhada V.1

Affiliation:

1. Chiplunkar Laboratory; Advanced Centre for Treatment; Research and Education in Cancer (ACTREC); Tata Memorial Centre; Kharghar Navi Mumbai India

2. Immunology Group; International Centre for Genetic Engineering and Biotechnology; New Delhi India

3. Tata Memorial Hospital; Mumbai India

Publisher

Wiley

Subject

Immunology,Immunology and Allergy

Reference60 articles.

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2. Signaling abnormalities, apoptosis, and reduced proliferation of circulating and tumor-infiltrating lymphocytes in patients with oral carcinoma;Reichert;Clin Cancer Res,2002

3. Alterations in T cell receptor and signal transduction molecules in melanoma patients;Zea;Clin Cancer Res,1995

4. Immune cells in the tumor microenvironment. Mechanisms responsible for functional and signaling defects;Whiteside;Adv Exp Med Biol,1998

5. Loss of T-cell receptor-CD3ζ and T-cell function in tumor-infiltrating lymphocytes but not in tumor-associated lymphocytes in ovarian carcinoma;Lockhart;Surgery,2001

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