YH12852, a potent and highly selective 5-HT4 receptor agonist, significantly improves both upper and lower gastrointestinal motility in a guinea pig model of postoperative ileus

Author:

Hussain Z.1,Lee Y. J.1,Yang H.2,Jeong E. J.3,Sim J. Y.3,Park H.1ORCID

Affiliation:

1. Department of Internal Medicine; Gangnam Severance Hospital; Yonsei University College of Medicine; Seoul Korea

2. Washington University; St. Louis MO USA

3. Yuhan R&D Institute; Yuhan Corporation; Seoul Korea

Funder

Yuhan R&D Institute

Yuhan Corporation

Publisher

Wiley

Subject

Gastroenterology,Endocrine and Autonomic Systems,Physiology

Reference44 articles.

1. Postoperative upper and lower gastrointestinal recovery and gastrointestinal morbidity in patients undergoing bowel resection: pooled analysis of placebo data from 3 randomized controlled trials;Delaney;Am J Surg,2006

2. Alvimopan, a novel, peripherally acting mu opioid antagonist: results of a multicenter, randomized, double-blind, placebo-controlled, phase III trial of major abdominal surgery and postoperative ileus;Wolff;Ann Surg,2004

3. Gum chewing reduces ileus after elective open sigmoid colectomy;Schuster;Arch Surg,2006

4. Economic burden of postoperative ileus associated with colectomy in the United States;Iyer;J Manag Care Pharm,2009

5. Reducing the burden of postoperative ileus: evaluating and implementing an evidence-based strategy;Barletta;World J Surg,2014

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