Down-Regulation of Asparagine Synthetase Induces Cell Cycle Arrest and Inhibits Cell Proliferation of Breast Cancer

Author:

Yang Hongjian1,He Xiangming1,Zheng Yabing2,Feng Weiliang1,Xia Xianghou1,Yu Xingfei1,Lin Zhiqiang3

Affiliation:

1. Department of Breast Surgery; Zhejiang Cancer Hospital; 38 Guangji Road Hangzhou 310022 China

2. Department of Internal Oncology; Zhejiang Cancer Hospital; 38 Guangji Road Hangzhou 310022 China

3. Zhejiang Cancer Research Institute; Zhejiang Cancer Hospital; 38 Guangji Road Hangzhou 310022 China

Funder

Foundation of Health Department of Zhejiang Province, China

Foundation of Science Technology Department of Zhejiang Province, China

Natural Science Foundation of Zhejiang Province, China

Traditional Chinese Medical Research Foundation of Zhejiang Province, China

Publisher

Wiley

Subject

Molecular Medicine,Biochemistry,Drug Discovery,Pharmacology,Organic Chemistry

Reference30 articles.

1. Global cancer statistics;Jemal;CA Cancer J Clin,2011

2. Cancer statistics, 2006;Jemal;CA Cancer J Clin,2006

3. American Cancer Society Cancer Facts & Figures Atlanta, GA The Society

4. Mechanistic issues in asparagine synthetase catalysis;Richards;Adv Enzymol Relat Areas Mol Biol,1998

5. Asparagine synthetase in asparaginase resistant and susceptible mouse lymphomas;Prager;Biochem Biophys Res Commun,1968

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