Enhanced potency of recombinant factor VIIa with increased affinity to activated platelets
Author:
Affiliation:
1. Novo Nordisk A/S Måløv Denmark
2. Department of Pharmacotherapy and Outcomes Science Virginia Commonwealth University Richmond VA USA
Publisher
Wiley
Subject
Hematology
Link
https://onlinelibrary.wiley.com/doi/pdf/10.1111/jth.14644
Reference23 articles.
1. A cell-based model of coagulation and the role of factor VIIa
2. The role of cell surfaces and cellular receptors in the mode of action of recombinant factor VIIa
3. Preferential localization of recombinant factor VIIa to platelets activated with a combination of thrombin and a glycoprotein VI receptor agonist
4. Platelet binding and activity of a factor VIIa variant with enhanced tissue factor independent activity
5. The glycoprotein Ib-IX-V complex contributes to tissue factor–independent thrombin generation by recombinant factor VIIa on the activated platelet surface
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