PDGFRAAmplification is Common in Pediatric and Adult High-Grade Astrocytomas and Identifies a Poor Prognostic Group in IDH1 Mutant Glioblastoma

Author:

Phillips Joanna J.,Aranda Derick,Ellison David W.1,Judkins Alexander R.2,Croul Sidney E.3,Brat Daniel J.4,Ligon Keith L.5,Horbinski Craig6,Venneti Sriram7,Zadeh Gelareh8,Santi Mariarita9,Zhou Shengmei2,Appin Christina L.4,Sioletic Stefano10,Sullivan Lisa M.9,Martinez-Lage Maria11,Robinson Aaron E.,Yong William H.12,Cloughesy Timothy13,Lai Albert13,Phillips Heidi S.14,Marshall Roxanne,Mueller Sabine,Haas-Kogan Daphne A.,Molinaro Annette M.,Perry Arie

Affiliation:

1. Department of Pathology; St. Jude Children's Research Hospital; Memphis; TN

2. Department of Pathology; Children's Hospital Los Angeles

3. Department of Lab Medicine and Pathobiology; Toronto Western Hospital; University of Toronto; Toronto; ON; Canada

4. Department of Pathology and Laboratory Medicine; Emory University, Emory University School of Medicine; Atlanta; GA

5. Department of Medical Oncology and Center for Molecular Oncologic Pathology; Dana Farber Cancer Institute; Boston; MA

6. Department of Pathology & Laboratory Medicine; University of Kentucky; Lexington; KY

7. Memorial Sloan-Kettering Cancer Center; New York; NY

8. Division of Neurosurgery; Toronto Western Hospital; University of Toronto; Toronto; ON; Canada

9. Department of Pathology and Laboratory Medicine; The Children's Hospital of Philadelphia; Philadelphia; PA

10. Department of Pathology; Brigham and Women's Hospital and Harvard Medical School; Boston; MA

11. Department of Pathology and Laboratory Medicine; University of Pennsylvania Health System; Philadelphia; PA

12. Department of Pathology and Laboratory Medicine; David Geffen School of Medicine at the University of California Los Angeles; Los Angeles; CA

13. Department of Neurology; David Geffen School of Medicine at the University of California Los Angeles; Los Angeles; CA

14. Department of Drug Metabolism and Pharmacokinetics; Genentech Inc.; San Francisco; CA

Publisher

Wiley

Subject

Neurology (clinical),Pathology and Forensic Medicine,General Neuroscience

Reference32 articles.

1. Prevalence, clinico-pathological value, and co-occurrence of PDGFRA abnormalities in diffuse gliomas;Alentorn;Neuro-Oncol,2012

2. The t(4;22)(q12;q11) in a typical chronic myeloid leukaemia fuses BCR to PDGFRA;Baxter;Hum Mol Genet,2002

3. Glioblastoma subclasses can be defined by activity among signal transduction pathways and associated genomic alterations;Brennan;PLoS ONE,2009

4. CBTRUS 2011 CBTRUS statistical report: primary brain and central nervous system tumors diagnosed in the United States in 2004-2007 http://www.cbtrus.org

5. Magnetic resonance of 2-hydroxyglutarate in IDH1-mutated low-grade gliomas;Elkhaled;Sci Transl Med,2012

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