Synthesis and Biological Evaluation of Strictosamide Derivatives with Improved Antiviral and Antiproliferative Activities

Author:

Li Zan1,Li Zhaoliang123,Lin Yunwei1,Meng Zhaoqing23,Ding Gang23,Cao Liang23,Li Na23,Liu Wenjun23,Xiao Wei23,Wu Xiaoming1,Xu Jinyi1

Affiliation:

1. State Key Laboratory of Natural Medicines and Department of Medicinal Chemistry; China Pharmaceutical University; 24 Tong Jia Xiang Nanjing 210009 China

2. Jiangsu Zeukov Pharmaceutical S&T. Inc; Jiangsu Nanjing 210017 China

3. State Key Lab of New-tech for Chinese Medicine Pharmaceutical Process; Jiangsu Lianyungang 222001 China

Funder

Eleventh Five-Year

Program of State Key Laboratory of Natural Medicines

China Pharmaceutical University

Publisher

Wiley

Subject

Molecular Medicine,Biochemistry,Drug Discovery,Pharmacology,Organic Chemistry

Reference18 articles.

1. The conversion of oridonin to spirolactone-type or enmein-type diterpenoid, synthesis and biological evaluation of ent-6,7-seco-oridonin derivatives as novel potential anticancer agents;Wang;Eur J Med Chem,2012

2. Recent progress in the development of natural ent-kaurane diterpenoids with anti-tumor activity;Wang;Mini-Rev Med Chem,2011

3. Synthesis and biological evaluation of 14-O-derivatives of natural oridonin;Wang;Chin J Nat Med,2011

4. Synthesis and biological evaluation of novel furozan-based nitric oxide-releasing derivatives of oridonin as potential anti-tumor agents;Li;Molecules,2012

5. Synthesis of novel furozan-based nitric oxide-releasing derivatives of 1-oxo-oridonin with anti-proliferative activity;Li;Chin J Nat Med,2012

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