Combined Molecular Docking, 3D-QSAR, and Pharmacophore Model: Design of Novel Tubulin Polymerization Inhibitors by Binding to Colchicine-binding Site-Reference-Cited by-同舟云学术

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Combined Molecular Docking, 3D-QSAR, and Pharmacophore Model: Design of Novel Tubulin Polymerization Inhibitors by Binding to Colchicine-binding Site

Published:2015-03-20 Issue:4 Volume:86 Page:731-745
ISSN:1747-0277
Container-title:Chemical Biology & Drug Design
language:en
Short-container-title:Chem Biol Drug Des

Author:

Li Dong-Dong¹,Qin Ya-Juan²,Zhang Xin²,Yin Yong²,Zhu Hai-Liang²,Zhao Lin-Guo¹

Affiliation:

1. College of Chemical Engineering; Nanjing Forestry University; Nanjing 210073 China

2. State Key Laboratory of Pharmaceutical Biotechnology; School of Life Sciences; Nanjing University; Nanjing 210093 China

Funder

Control and Rectification of Water Body Pollution

Foundation of Henan Educational Committee

Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)

Publisher

Wiley

Subject

Molecular Medicine,Biochemistry,Drug Discovery,Pharmacology,Organic Chemistry

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1111/cbdd.12545/fullpdf

Reference44 articles.

1. Microtubules as a target for anticancer drugs;Jordan;Nat Rev Cancer,2004

2. Microtubule-binding agents: a dynamic field of cancer therapeutics;Dumontet;Nat Rev Drug Discov,2010

3. An overview of tubulin inhibitors that interact with the colchicine binding site;Lu;Pharm Res,2012

4. A Phase Ib trial of CA4P (combretastatin A-4 phosphate), carboplatin, and paclitaxel in patients with advanced cancer;Rustin;Br J Cancer,2010

5. Discovery of novel tubulin inhibitors via structure-based hierarchical virtual screening;Cao;J Chem Inf Model,2012

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1. Interaction of norsecurinine-type monomeric and dimeric alkaloids with α-tubulin: a molecular docking study;Exploration of Drug Science;2024-05-21

2. Identification of anti-cancer natural compounds against colchicine binding site of tubulin: a combined structure and QSAR-based approach;Molecular Simulation;2023-05-19

3. Recent Advances of Tubulin Inhibitors Targeting the Colchicine Binding Site for Cancer Therapy;Biomolecules;2022-12-10

4. Synthesis and characterization of novel combretastatin analogues of 1,1-diaryl vinyl sulfones, with antiproliferative potential via in-silico and in-vitro studies;Scientific Reports;2022-02-03

5. Development of predictive in silico cytotoxic activity model to predict the cytotoxicity of a diverse set of colchicine binding site inhibitors;Eurasian Journal of Medicine and Oncology;2022

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