Multiple genetically modified GTKO/hCD46/HLA-E/hβ2−mg porcine hearts are protected from complement activation and natural killer cell infiltration during ex vivo perfusion with human blood-Reference-Cited by-同舟云学术

Multiple genetically modified GTKO/hCD46/HLA-E/hβ2−mg porcine hearts are protected from complement activation and natural killer cell infiltration during ex vivo perfusion with human blood

Published:2018-03-14 Issue:5 Volume:25 Page:e12390
ISSN:0908-665X
Container-title:Xenotransplantation
language:en
Short-container-title:Xenotransplantation

Author:

Abicht Jan-Michael¹^ORCID,Sfriso Riccardo²^ORCID,Reichart Bruno³,Längin Matthias¹^ORCID,Gahle Katja¹,Puga Yung Gisella L.⁴^ORCID,Seebach Jörg D.⁴^ORCID,Rieben Robert²^ORCID,Ayares David⁵,Wolf Eckhard⁶,Klymiuk Nikolai⁶,Baehr Andrea⁶,Kind Alexander⁷,Mayr Tanja¹,Bauer Andreas¹

Affiliation:

1. Department of Anaesthesiology; Ludwig Maximilian University; Munich Germany

2. Department of Clinical Research; University of Bern; Bern Switzerland

3. Transregio Collaborative Research Center 127; Walter Brendel Centre of Experimental Medicine; Ludwig Maximilian University; Munich Germany

4. Division of Immunology and Allergology; University Hospital and Faculty of Medicine; University of Geneva; Geneva Switzerland

5. Revivicor; Blacksburg VA USA

6. Department of Molecular Animal Breeding and Biotechnology; Ludwig Maximilian University; Munich Germany

7. Chair of Livestock Biotechnology; School of Life Sciences Weihenstephan; Technical University of Munich; Munich Germany

Funder

Deutsche Forschungsgemeinschaft

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

Publisher

Wiley

Subject

Transplantation,Immunology

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1111/xen.12390/fullpdf

Reference34 articles.

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2. Production of α1,3-galactosyltransferase-deficient pigs;Phelps;Science,2003

3. Heart transplantation in baboons using α1,3-galactosyltransferase gene-knockout pigs as donors: initial experience;Kuwaki;Nat Med,2005

4. Marked prolongation of porcine renal xenograft survival in baboons through the use of alpha1,3-galactosyltransferase gene-knockout donors and the cotransplantation of vascularized thymic tissue;Yamada;Nat Med,2005

5. Membrane complement regulatory proteins;Kim;Clin Immunol,2006

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