The novel atypical retinoid ST5589 down-regulates Aurora Kinase A and has anti-tumour activity in lymphoma pre-clinical models

Author:

Bernasconi Elena1,Gaudio Eugenio1,Kwee Ivo123,Rinaldi Andrea1,Cascione Luciano14,Tarantelli Chiara1,Mensah Afua Adjeiwaa1,Stathis Anastasios4,Zucca Emanuele4,Vesci Loredana5,Giannini Giuseppe5,Bertoni Francesco14

Affiliation:

1. Lymphoma and Genomics Research Program; IOR Institute of Oncology Research; Bellinzona Switzerland

2. Dalle Molle Institute for Artificial Intelligence (IDSIA); Manno Switzerland

3. SIB Swiss Institute of Bioinformatics; Lausanne Switzerland

4. IOSI Oncology Institute of Southern Switzerland; Bellinzona Switzerland

5. Research & Development; Sigma-Tau; Pomezia Italy

Funder

Sigma-Tau

Nelia et Amadeo Barletta Foundation

Gelu Foundation

Publisher

Wiley

Subject

Hematology

Reference28 articles.

1. The BET bromodomain inhibitor OTX015 affects pathogenetic pathways in preclinical B-cell tumor models and synergizes with targeted drugs;Boi;Clinical Cancer Research,2015

2. Deregulation of ETS1 and FLI1 contributes to the pathogenesis of diffuse large B-cell lymphoma;Bonetti;Blood,2013

3. Cabri , W. Giannini , G. Battistuzzi , G. Alloatti , D. Pisano , C. Dallavalle , S. Brunetti , T. 2010 New retinoid derivatives endowed with cytotoxic and/or antiangiogenic properties

4. Preclinical versus clinical drug combination studies;Chou;Leukaemia & Lymphoma,2008

5. A novel atypical retinoid endowed with proapoptotic and antitumor activity;Cincinelli;Journal of Medicinal Chemistry,2003

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