Deregulation of ETS1 and FLI1 contributes to the pathogenesis of diffuse large B-cell lymphoma

Author:

Bonetti Paola1,Testoni Monica1,Scandurra Marta1,Ponzoni Maurilio2,Piva Roberto34,Mensah Afua A.1,Rinaldi Andrea1,Kwee Ivo156,Tibiletti Maria Grazia7,Iqbal Javeed8,Greiner Timothy C.8,Chan Wing-Chung8,Gaidano Gianluca9,Piris Miguel A.10,Cavalli Franco11,Zucca Emanuele11,Inghirami Giorgio34,Bertoni Francesco111

Affiliation:

1. Lymphoma and Genomics Research Program, Institute of Oncology Research, Bellinzona, Switzerland;

2. Pathology Unit, Unit of Lymphoid Malignancies, Ospedale San Raffaele Scientific Institute, Milan, Italy;

3. Department of Pathology and Center for Experimental Research and Medical Studies, University of Turin, Italy;

4. Department of Pathology, and NYU Cancer Center, New York University School of Medicine, New York, NY;

5. Dalle Molle Institute for Artificial Intelligence, Manno, Switzerland;

6. Swiss Institute of Bioinformatics, Lausanne, Switzerland;

7. Anatomic Pathology Unit, University of Insubria, Ospedale di Circolo, Varese, Italy;

8. Department of Pathology and Microbiology, University of Nebraska, Omaha, NE;

9. Division of Hematology, Department of Translational Medicine, Amedeo Avogadro University of Eastern Piedmont, Novara, Italy;

10. Hospital Universitario Marques de Valdecilla, Fundacion Fundación Marques de Valdecilla, Santander, Spain; and

11. Oncology Institute of Southern Switzerland, Bellinzona, Switzerland.

Abstract

Key Points A recurrent gain of a region of chromosome 11 (11q24.3) occurs in up to one-quarter of cases of diffuse large B-cell lymphoma. ETS1 and FLI1 genes are overexpressed and determine proliferation, survival, and differentiation arrest of the lymphoma cells.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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