I nhibition of microsomal PGE synthase-1 reduces human vascular tone by increasing PGI2 : a safer alternative to COX-2 inhibition

Author:

Ozen Gulsev12,Gomez Ingrid13,Daci Armond2,Deschildre Catherine1,Boubaya Lilia1,Teskin Onder4,Uydeş-Doğan B Sonmez2,Jakobsson Per-Johan5,Longrois Dan16,Topal Gokce2,Norel Xavier17ORCID

Affiliation:

1. INSERM U1148; Paris France

2. Faculty of Pharmacy, Department of Pharmacology; Istanbul University; Istanbul Turkey

3. Department of Infection, Immunity and Cardiovascular Disease, School of Medicine and Biomedical Sciences; University of Sheffield; Sheffield UK

4. Department of Cardiovascular Surgery; Aile Hospital; Istanbul Turkey

5. Unit of Rheumatology, Department of Medicine Solna, Karolinska Institute and Unit of Rheumatology; Karolinska University Hospital; Stockholm Sweden

6. AP-HP CHU X. Bichat, Department of Anesthesia and Intensive Care; University Paris Diderot, Sorbonne Paris-Cité, UMR-S1148; Paris France

7. University Paris Diderot, Sorbonne Paris-Cité, UMR-S1148; Paris France

Funder

Türkiye Bilimsel ve Teknolojik Araştirma Kurumu

Institut National de la Santé et de la Recherche Médicale

Publisher

Wiley

Subject

Pharmacology

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