Identification of 2-Aminoacyl-1,3,4-thiadiazoles as Prostaglandin E<sub>2</sub> and Leukotriene Biosynthesis Inhibitors-Reference-Cited by-同舟云学术

Identification of 2-Aminoacyl-1,3,4-thiadiazoles as Prostaglandin E₂ and Leukotriene Biosynthesis Inhibitors

Published:2022-12-09 Issue:1 Volume:14 Page:26-34
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Potenza Marianna¹²,Giordano Assunta¹³,Chini Maria G.⁴,Saviano Anella⁵,Kretzer Christian⁶,Raucci Federica⁵,Russo Marina⁵,Lauro Gianluigi¹^ORCID,Terracciano Stefania¹,Bruno Ines¹,Iorizzi Maria⁴,Hofstetter Robert K.⁶^ORCID,Pace Simona⁶,Maione Francesco⁵,Werz Oliver⁶^ORCID,Bifulco Giuseppe¹^ORCID

Affiliation:

1. Department of Pharmacy, University of Salerno, via Giovanni Paolo II, 132, 84084, Fisciano, Italy

2. The FIRC Institute of Molecular Oncology, Via Adamello 16, 20139 Milan, Italy

3. Institute of Biomolecular Chemistry (ICB), Consiglio Nazionale delle Ricerche (CNR), Via Campi Flegrei 34, Pozzuoli, 80078 Napoli, Italy

4. Department of Biosciences and Territory, University of Molise, Contrada Fonte Lappone, Pesche, 86090 Isernia, Italy

5. ImmunoPharmaLab, Department of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Via Domenico Montesano 49, 80131 Naples, Italy

6. Department of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Friedrich Schiller University Jena, Philosophenweg 14, 07743 Jena, Germany

Funder

Associazione Italiana per la Ricerca sul Cancro

Deutsche Forschungsgemeinschaft

Universit? degli Studi di Napoli Federico II

Ministero dell'Universit? e della Ricerca

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.2c00343

Reference35 articles.

1. A review on mPGES-1 inhibitors: From preclinical studies to clinical applications

2. Crystal structures of human MGST2 reveal synchronized conformational changes regulating catalysis

3. Lipoxygenase and Leukotriene Pathways: Biochemistry, Biology, and Roles in Disease

4. Enzymes of the Cyclooxygenase Pathways of Prostanoid Biosynthesis

5. I nhibition of microsomal PGE synthase-1 reduces human vascular tone by increasing PGI2 : a safer alternative to COX-2 inhibition